Thiruvananthapuram: An Indian scientist, Saritha Krishna, leading a team of researchers from the University of California’s San Francisco Medical Centre, has made a groundbreaking discovery in the treatment of cancerous brain tumours. The study reveals that cancer cells in the brain establish connections with healthy brain cells, leading to rapid cognitive decline and ultimately causing the death of patients.
In their research, the team found that a commonly used anti-seizure drug effectively reduces the hyperactivity of tumour cells and halts their growth. This significant finding holds great potential for transforming the treatment of glioblastoma, the most fatal form of adult brain cancer.
Saritha Krishna, a native of Thiruvananthapuram, Kerala, and the lead author of the study highlighted the importance of their findings. The study not only uncovers the intricate communication between healthy and cancerous brain cells but also identifies the potential of repurposing existing medications like gabapentin to target tumour growth and expedite therapeutic advancements for patients with malignant glioma.
Moreover, the discovery of how cancer cells hijack and restructure brain circuitry offers prospects for developing innovative drugs and neuromodulation techniques. These interventions could effectively disconnect neuronal linkups with brain cancer cells, leading to the suppression of tumour growth. The study’s findings may pave the way for clinical trials and the exploration of non-invasive brain modulation techniques traditionally used in epilepsy and psychiatric diseases.