Scientists Develop New Technology To Decode Degenerative Brain Disorders

South Korean scientists at the Korea Institute of Science and Technology (KIST) have introduced a cutting-edge labelling technology called NeuM (Neuronal Membrane-selective), aimed at decoding degenerative brain disorders like Alzheimer’s, Parkinson’s disease, and stroke. This innovative method allows for detailed observation of neuronal structures, crucial for understanding nerve cell malfunction and degeneration.

NeuM enables real-time monitoring of neuronal changes by selectively labelling neuronal membranes. Unlike existing gene-based and antibody-based technologies, NeuM offers high accuracy and long-term tracking capabilities. Its molecular design ensures excellent binding affinity to neuronal membranes, facilitating high-resolution imaging over 72 hours.

Dr. Kim Yun Kyung from KIST’s Brain Science Institute emphasizes NeuM’s potential in distinguishing ageing and degenerating neurons, which is vital for unravelling the mechanisms behind degenerative brain disorders and developing effective treatments. Future plans involve refining NeuM for even more precise neuronal analysis, including the ability to differentiate between colours such as green and red for enhanced insights.